Why I Take Lithium

Welcome to another edition of the Doctor’s Note where we talk about what’s on our minds when it comes to your health.

This week on the podcast I dove into a fascinating and often misunderstood supplement: Lithium Orotate. Many people haven’t even heard of using lithium in low doses as an anti-aging supplement, and that’s exactly why I wanted to shed some light on it. Although lithium has a long history as a treatment for bipolar (formerly manic-depressive) disorders in high doses, what we’re talking about here is a very different, safe, and over-the-counter variety—lithium orotate. I personally include it in my own supplement routine at age 70 for prevention of dementia, and as I have said before, if I wouldn’t take it myself, I wouldn’t recommend it to you. My focus is on how lithium orotate is gaining attention among longevity enthusiasts and why it might be worth your consideration for its neuroprotective and mood-stabilizing qualities.

As I walked through the history of lithium’s use—from its early days in groundwater and even 7Up, to its classic role in psychiatry—I wanted to clarify that the low-dose, non-prescription form (lithium orotate) is not the same as prescription lithium carbonate for psychiatric conditions. I highlighted the benefits, potential mechanisms (like mitochondrial support and autophagy), and why I cycle this supplement in my regimen for brain health, longevity, and overall wellness. I also emphasized the importance of doing your own research, listening to experienced sources like Peter Attia, and making common sense decisions about what’s right for you as you age.

PODCAST NOTES

• Lithium Orotate vs. Prescription Lithium: Lithium orotate is a low-dose, over-the-counter supplement form of lithium that is distinct from the prescription lithium carbonate used for treating severe psychiatric disorders like bipolar disorder. Prescription lithium, while effective as a mood stabilizer, requires regular monitoring due to its narrow therapeutic window and potential for kidney and thyroid toxicity. Lithium orotate, in contrast, is taken in much smaller doses, does not require blood level monitoring, and is considered much safer for general use when used responsibly.

• Safety and Accessibility of Lithium Orotate: One of the main reasons I recommend lithium orotate is its excellent safety profile at low doses when sourced from reputable brands. Users are unlikely to experience significant side effects, especially when cycling the supplement rather than taking it continuously. This is a big contrast to the risks associated with long-term high-dose prescription lithium. Plus, being available over the counter means access is simple—no doctor’s script required, yet always check with your provider before starting.

• Historical Curiosities—Lithium in 7Up: Not everyone knows that lithium has a quirky place in American history—even making its way into the original formulation of 7Up! This reflected the mineral’s reputation as a mood enhancer long before modern psychiatric uses took shape. Lithium was only removed from 7Up in 1929, highlighting society’s evolving relationship with mood-altering substances and the influence of regulatory pressures on public health.

• Neuroprotective and Cellular Health Benefits: Emerging research suggests that lithium orotate may be beneficial for brain health. Its neuroprotective effects are related to its role in supporting mitochondrial function—the “energy factories” of our cells—and promoting autophagy, a process where damaged cells are cleared out of the body. Both are fundamental aspects of healthy aging and may help stave off cognitive decline.

• Telomere Maintenance for Longevity: Lithium orotate is thought to positively influence telomere length—the protective “caps” at the end of our chromosomes that shorten as we age. Maintaining telomere health is increasingly recognized as a marker for longevity, and lithium orotate might help slow this aspect of cellular aging, although more definitive research is still needed.

• Mechanism: Inhibition of GSK3 Enzymes: A key mechanism through which lithium exerts its benefits is the inhibition of the GSK3 enzyme. This enzyme is implicated in a broad range of health conditions, including Alzheimer’s, Parkinson’s, other neurodegenerative diseases, bipolar disorder, type 2 diabetes, and even some cancers. While effects can vary, lithium’s ability to modulate GSK3 activity might underlie its wide-ranging potential in promoting brain and metabolic health.

• Supplement Cycling and Sourcing: I recommend cycling lithium orotate (and most other supplements) rather than taking them every single day, as periodic breaks may enhance efficacy and limit the chance of side effects or tolerance. When sourcing, I look for purity and minimal fillers—my go-to is Life Extension due to their higher standards and competitive pricing (around $12 for a supply). Remember, the form and brand of any supplement matter as much as the compound itself.

• Critical Thinking and Not Confusing Similar Names: With so many new “longevity” supplements on the market, it’s easy to confuse names. Lithium orotate is sometimes mistaken for urolithin A (found in costly mitopure blends from pomegranates), but they are completely different substances with distinct mechanisms and benefits. Always check not just the name but the science behind any supplement, and remain skeptical until you’ve done your own research and consulted with trusted healthcare professionals.

My goal is always to break down complex topics and help you make informed, practical choices about your health. Lithium orotate is a fascinating and affordable addition to the world of longevity supplements—one I personally use and recommend if you’re interested in brain health, mood stability, and slowing aspects of cellular aging. Just a few days ago, The Wall Street Journal (Aug. 10, 2025) reported:

“A study published in the journal Nature found that amyloid can trap lithium, resulting in a deficiency of the mineral. Lithium protects neurons. Mice given a lithium-deficient diet had more amyloid, damaged neurons, and impaired learning and memory. A low dose of lithium orotate reversed cognitive problems and restored memory.”

As I’ve said before, if I wouldn’t take it myself, I wouldn’t recommend it to you. Before adding any supplement to your health regimen, be sure to discuss it with your healthcare provider. Stay curious, do your own homework, and keep tuning in to the podcast for more common sense health tips.

If you have any questions, reach out to us at Performance Medicine—and don’t forget to follow along for daily updates and next week’s episode!

Till next week.

Stay educated. Stay healthy.